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万密密博士和毛春教授课题组在JOURNAL OF MATERIALS CHEMISTRY B发表研究论文

发布时间:17-08-04 15:29:39 文章来源:1 浏览次数: [ 字号:


A novel H2O2 biosensor based on three-dimensional micro/nano-biointerfaces
Wang, Q (Wang, Qi)[ 1 ] ; Hu, SS (Hu, Sisheng)[ 2 ] ; Yang, T (Yang, Tian)[ 1 ] ; Ma, SS (Ma, Shangshang)[ 1 ] ; Liu, YH (Liu, Yuhong)[ 1 ] ; Ma, CX (Ma, Chunxue)[ 1 ] ; Wan, MM (Wan, Mimi)[ 1 ]*(万密密); Mao, C (Mao, Chun)[ 1 ]*(毛春)

[ 1 ] Nanjing Normal Univ, Sch Chem & Mat Sci, Natl & Local Joint Engn Res Ctr Biomed Funct Mat, Jiangsu Key Lab Biofunct Mat, Nanjing 210023, Jiangsu, Peoples R China
[ 2 ] Nanjing Univ, Inst Chem & BioMed Sci, Sch Life Sci, State Key Lab Pharmaceut Biotechnol, Nanjing 210093, Jiangsu, Peoples R China

JOURNAL OF MATERIALS CHEMISTRY B,201706,5(22),4233-4238

To detect hydrogen peroxide (H2O2) that is released in situ by cells is a challenge because of its high activity and short life time. Here, a new type of H2O2 biosensor was reported based on three-dimensional (3D) micro/nano-biointerfaces as an amicable platform to promote cell adhesion, and which can directly grow living cells on manganese dioxide (MnO2) immobilized onto a novel hollow horn-like morphology polypyrrole (hPPy) film. The composite MnO2/hPPy array films were characterized by scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS) and elemental mapping. Further, the results of a cell adhesion test indicated that the as-obtained 3D micro/nano-array films had good cell adhesion. This proposed sensing platform provided high electroactivity and excellent electron transport with a lower detection limit, a higher sensitivity and a short diffusion distance to reaction sites by electrochemical study. The new design strategy we proposed can expand the bioapplication of 3D micro/nano-biointerfaces that can guide cell fate and electrochemical detection in cell biology.

文章链接:
http://pubs.rsc.org/en/Content/ArticleLanding/2017/TB/C7TB00353F#!divAbstract
 
 


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