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刘平生教授和李利教授课题组合作在JOURNAL OF MATERIALS CHEMISTRY B发表研究论文

发布时间:17-08-04 14:33:15 文章来源:1 浏览次数: [ 字号:


Zwitterionic copolymers bearing phosphonate or phosphonic motifs as novel metal-anchorable anti-fouling coatings
Huang, T (Huang, Tao)[ 1 ] ; Liu, HW (Liu, Hongwei)[ 1 ] ; Liu, PM (Liu, Peiming)[ 1 ] ; Liu, PS (Liu, Pingsheng)[ 1 ]*(刘平生); Li, L (Li, Li)[ 1 ]*(李利); Shen, J (Shen, Jian)[ 1,2 ]

[ 1 ] Nanjing Normal Univ, Jiangsu Collaborat Innovat Ctr Biomed Funct Mat, Jiangsu Key Lab Biofunct Mat, Sch Chem & Mat Sci, Nanjing 210023, Jiangsu, Peoples R China
[ 2 ] Nanjing Univ, Sch Chem & Chem Engn, Nanjing 210093, Jiangsu, Peoples R China

JOURNAL OF MATERIALS CHEMISTRY B,201707,5(27),5380-5389

Developing a facile but efficient anti-fouling surface coating is highly required for metallic implants. Here, we report two kinds of zwitterionic copolymers (both random and block) bearing phosphonic/phosphonate motifs/segments as novel metal anchorable antifouling coatings. Through conventional free radical polymerization and reversible addition-fragmentation chain transfer (RAFT) polymerization, three types of zwitterionic-phosphonic random copolymers with varying mol. ratios (9 : 1, 8 : 2, and 6 : 4) and a phosphonate-zwitterionic block copolymer were precisely prepared based on zwitterionic sulfobetaine methacrylate (SBMA) and phosphonate/phosphonic methacrylate. As evidenced by XPS and water contact angle tests, the two kinds of copolymers with distinguished presenting manners of the metal-anchorable phosphonate/phosphonic motifs were all successfully immobilized on the Ti substrates through a facile one-step post-functionalization. The immobilized copolymers equally exhibited strong inhibition of protein adsorption, platelet adhesion, and bacterial adhesion, endowing significantly improved antifouling ability to the metallic substrates. This work not only provides a novel approach to improve the antifouling ability of Ti substrates, the utilization of phosphonic/phosphonate based copolymers as efficient metal-anchorable coatings may offer a new platform for versatile surface functionalization of many metallic substrates.


文章链接:
http://pubs.rsc.org/en/Content/ArticleLanding/2017/TB/C7TB01017F#!divAbstract
 


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