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马振叶教授和韩巧荣副教授课题组在MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS发表研究论文

发布时间:17-08-04 14:29:31 文章来源:1 浏览次数: [ 字号:


A facile one-step method for preparation of Fe3O4CSINH nanoparticles as a targeted drug delivery for tuberculosis
Zhao, CL (Zhao, Chili)[ 1 ] ; Liu, X (Liu, Xun)[ 2 ] ; Zhang, X (Zhang, Xia)[ 3 ] ; Yan, H (Yan, Hong)[ 3 ] ; Qian, ZL (Qian, Zhilei)[ 3 ] ; Li, XH (Li, Xinghui)[ 1 ] ; Ma, ZY (Ma, Zhenye)[ 1 ]*(马振叶) ; Han, QR (Han, Qiaorong)[ 1 ]*(韩巧荣) ; Pei, CH (Pei, Chonghua)[ 1 ]*

[ 1 ] Nanjing Normal Univ, Sch Chem & Mat Sci, Nanjing 210046, Jiangsu, Peoples R China
[ 2 ] Southwest Univ Sci & Technol, State Key Lab Cultivat Base Nonmet Composite & Fu, Mianyang 621010, Peoples R China
[ 3 ] Nanjing Chest Hosp, Nanjing 210097, Jiangsu, Peoples R China

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,201708,77,1182-1188

In this paper, Fe3O4/chitosan/isoniazid magnetic nanoparticles (Fe3O4/CS/INH-MNPs) were prepared as an environmental stimuli-responsive drug-delivery system by automated in situ click technology, in which Fe3O4 magnetic nanoparticles, chitosan and isoniazid were simultaneously in situ crystallized by one-step method. The Fe3O4 magnetic nanoparticles and tripolyphosphate act as stable crosslinkers to produce numerous intermolecular crosslinkages for the mobility of the chitosan chains. Characterization results indicated that the multifunctional drug delivery system with optimized size, excellent loading capacity, well magnetic properties, nontoxicity and pH triggered drug release property is expected to be applied in tuberculosis treatment with excellent magnetic sensitivity and sustained release.


文章链接:
http://www.sciencedirect.com/science/article/pii/S0928493116312292?via%3Dihub
 


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