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万密密博士和毛春教授课题组在LANGMUIR发表研究论文

发布时间:17-07-02 13:00:50 文章来源:1 浏览次数: [ 字号:


Mesoporous Silica Nanoparticles-Encapsulated Agarose and Heparin as Anticoagulant and Resisting Bacterial Adhesion Coating for Biomedical Silicone
Wu, F (Wu, Fan)[ 1 ] ; Xu, TT (Xu, Tingting)[ 1,2 ] ; Zhao, GY (Zhao, Guangyao)[ 1 ] ; Meng, SS (Meng, Shuangshuang)[ 1 ] ; Wan, MM (Wan, Mimi)[ 1 ]*(万密密); Chi, B (Chi, Bo)[ 2 ] ; Mao, C (Mao, Chun)[ 1 ]*(毛春); Shen, J (Shen, Jian)[ 1 ]

[ 1 ] Nanjing Normal Univ, Sch Chem & Mat Sci, Jiangsu Key Lab Biofunct Mat, Natl & Local Joint Engn Res Ctr Bionied Funct Mat, Nanjing 210023, Jiangsu, Peoples R China
[ 2 ] Nanjing Tech Univ, Coll Food Sci & Light Ind, State Key Lab Mat Oriented Chem Engn, Nanjing 211816, Jiangsu, Peoples R China

LANGMUIR,201705,33(21),5245-5252

Silicone catheter has been widely used in peritoneal dialysis. The research missions of improving blood compatibility and the ability of resisting bacterial adhesion of silicone catheter have been implemented for the biomedical requirements. However, most of modification methods of surface modification were only able to deVelop the blood-contacting biomaterials with good hemocompatibility. It is difficult for the biornaterials to resist bacterial adhesion. Here, agarose was selected to resist 'bacterial adhesion, and heparin was chosen to improve hemocompatibility of materials. Both of them were loaded into mesoporous silica nanoparticles (MSNs), which were successfully modified on the silicone film surface via electrostatic interaction. Structures of the mesoporous coatings were characterized in detail by dynamic light scattering, transmission electron microscopy, Brunaner-Eminett Teller surface area, thermogravimetric analysis, Fourier transform infrared spectroScopy, scanning electron microscope, and water contact angle. Platelet adhesion and aggregation, whole blood contact test, hemolysis and related morphology test of red blood cells, in vitro clotting time tests, and bacterial adhesion assay were performed to evaluate the anticoagulant effect and the ability of resisting bacterial adhesion of the modified silicone films. Results indicated that silicone Bins modified by MSNs had good anticoagulant effect and could resist bacterial adhesion. The modified silicone films have potential as blood-contacting biomaterials that were attributed to their biomedical properties.


文章链接:
http://pubs.acs.org/doi/abs/10.1021/acs.langmuir.7b00567
 


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