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孙培培教授课题组在ORGANIC & BIOMOLECULAR CHEMISTRY发表研究论文

发布时间:17-04-06 13:32:54 文章来源:化科院 浏览次数: [ 字号:


Addition of nitrogen dioxide to carbon-carbon double bond followed by a cyclization to construct nitromethylated isoquinolinediones
Li, XX (Li, Xuanxuan); Zhuang, SY (Zhuang, Shengyi); Fang, XX (Fang, Xinxin); Liu, P (Liu, Ping); Sun, PP (Sun, Peipei)[ 1 ]*(孙培培)

[ 1 ] Nanjing Normal Univ, Coll Chem & Mat Sci, Jiangsu Prov Key Lab Mat Cycle Proc & Pollut Cont, Nanjing 210023, Jiangsu, Peoples R China
[ 2 ] Jiangsu Collaborat Innovat Ctr Biomed Funct Mat, Nanjing 210023, Jiangsu, Peoples R China

ORGANIC & BIOMOLECULAR CHEMISTRY, Jan.2017, 15(8), 1821-1827

Heterocyclic derivatives 4-(nitromethyl) isoquinoline-1,3(2H,4H)-diones were synthesized via a tandem nitration/cyclization reaction of N-alkyl-N-methacryloyl benzamides under metal-free conditions. The cheap and available reagent nitrogen dioxide was used as the nitro source, as well as the oxidant. For the substrates with various substituent groups, the reaction proceeded smoothly to give the corresponding isoquinolinedione derivatives in moderate to good yields. The products could be converted into aminomethyl or hydroxyl substituted heterocyclic derivatives by the simple reduction.


文章链接:
http://pubs.rsc.org/en/Content/ArticleLanding/2017/OB/C6OB02797K
 


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