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周宁琳教授课题组在RSC ADVANCES发表研究论文

发布时间:17-04-10 10:35:43 文章来源:化科院 浏览次数: [ 字号:


Graphene oxide and adenosine triphosphate as a source for functionalized carbon dots with applications in pH-triggered drug delivery and cell imaging
Zhang, M (Zhang, Ming)[ 1,2 ] ; Zhou, NL (Zhou, Ninglin)[ 1,2,3 ]*(周宁琳); Yuan, P (Yuan, Ping)[ 1,2 ] ; Su, YT (Su, Yutian)[ 1,2 ] ; Shao, MN (Shao, Maoni)[ 1,2 ] ; Chi, C (Chi, Cheng)[ 1,2 ]

[ 1 ] Nanjing Normal Univ, Jiangsu Collaborat Innovat Ctr Biol Funct Mat, Coll Chem & Mat Sci, Nanjing 210023, Jiangsu, Peoples R China
[ 2 ] Jiangsu Engn Res Ctr Biomed Funct Mat, Jiangsu Key Lab Biofunct Mat, Nanjing 210023, Jiangsu, Peoples R China
[ 3 ] Nanjing Zhou Ninglin Adv Mat Technol Co Ltd, Nanjing 211505, Jiangsu, Peoples R China

RSC ADVANCES, Jan.2017, 7(15), 9284-9293

A folate-functionalized carbon dot-based nanocarrier system has been successfully synthesized for cancer cell targeted drug delivery. We hydrothermally synthesized blue photoluminescent N, P-CDs using adenosine triphosphate and graphene oxide as the startingmaterials. The particle size of the N, P-CDswas ca. 3.8 nm. An anticancer drug, doxorubicin (DOX), was grafted onto the carbon dots via electrostatic interactions, and a more specific anticancer agent (DOX/N, P-CDs) was obtained. The DOX/N, P-CDs were characterized by H-NMR, C-NMR and UV-vis analysis. In addition, the DOX/N, P-CDs showed a pH-dependent release and were easily absorbed by cells. When compared to DOX, DOX/N, P-CDs nanoparticles exhibited the same cytotoxicity towards human cervical cancer cells (HeLa cells) and human pulmonary adenocarcinoma cells (A549 cells). Hemolysis test results indicated that DOX/N, P-CDs were safe for blood-contact applications and were suitable for intravenous administration. Owing to their intrinsic biocompatibility, N, P-CDs can be used for cell imaging and drug delivery with excellent targeting property.


文章链接:
http://pubs.rsc.org/en/Content/ArticleLanding/2017/RA/C6RA27887F#!divAbstract
 


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