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戴志晖教授课题组在ANALYTICAL CHEMISTRY发表研究论文

发布时间:17-12-19 16:48:18 文章来源:化科院 浏览次数: [ 字号:


Cucurbituril and Azide Cofunctionalized Graphene Oxide for Ultrasensitive Electro-Click Biosensing
Wei, TX (Wei, Tianxiang)[ 1,2 ] ; Dong, TT (Dong, Tingting)[ 1 ] ; Xing, H (Xing, Hong)[ 1 ] ; Liu, Y (Liu, Ying)[ 1 ] ; Dai, ZH (Dai, Zhihui)[ 1,3 ]*(戴志晖)

[ 1 ] Nanjing Normal Univ, Sch Chem & Mat Sci, Jiangsu Key Lab Biofunct Mat, Nanjing 210023, Jiangsu, Peoples R China
[ 2 ] Nanjing Normal Univ, Sch Environm, Nanjing 210023, Jiangsu, Peoples R China
[ 3 ] Nanjing Normal Univ, Ctr Anal & Testing, Nanjing 210023, Jiangsu, Peoples R China

ANALYTICAL CHEMISTRY,201711,89(22),12237-12243

To achieve high selectivity and sensitivity simultaneously in an electrochemical biosensing platform, cucurbituril and azide cofunctionalized graphene oxide, a new functional nanomaterial that acts as a go-between to connect the recognition element with amplified signal architecture, is developed in this work. The cucurbituril and azide cofunctionalized graphene oxide features a high specific surface area with abundant levels of the two types of functional groups. Specifically, it emerges as a powerful tool to link recognition elements with simplicity, high yield, rapidity, and highly selective reactivity through azide-alkynyl click chemistry. Moreover, it possesses many host molecules to interact with guest molecules (also signal molecules)-grafted branched ethylene imine polymer, through which the detection sensitivity can be greatly improved. Together with electro-click technology, a highly controllable, selective, and sensitive biosensing platform can be easily created. For VEGF165 protein detection, the electro-click assay has high selectivity and sensitivity; a dynamic detection range from 10 fg mL(-1) to 1 ng mL(-1) with a detection limit of 8 fg mL(-1) was achieved. The electro-click biosensing strategy based on cucurbituril and azide cofunctionalized graphene oxide would have great promise for other target analytes with a broad range of applications.


文章链接:
http://pubs.acs.org/doi/10.1021/acs.analchem.7b03068
 


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