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章峻副教授和周宁琳教授课题组合作在CHEMICAL ENGINEERING JOURNAL发表研究论文

发布时间:17-11-22 11:19:02 文章来源:化科院 浏览次数: [ 字号:


Magnetofluorescent photothermal micelles packaged with GdN@CQDs as photothermal and chemical dual-modal therapeutic agents
Zhang, M (Zhang, Ming)[ 1,2 ] ; Wang, J (Wang, Jing)[ 1,2 ] ; Wang, WT (Wang, Wentao)[ 4 ] ; Zhang, J (Zhang, Jun)[ 1,2 ]*(章峻); Zhou, NL (Zhou, Ninglin)[ 1,2,3 ]*(周宁琳)

[ 1 ] Nanjing Normal Univ, Jiangsu Collaborat Innovat Ctr Biol Funct Mat, Coll Chem & Mat Sci, Nanjing 210023, Jiangsu, Peoples R China
[ 2 ] Jiangsu Engn Res Ctr Biomed Funct Mat, Jiangsu Key Lab Biofunct Mat, Nanjing 210023, Jiangsu, Peoples R China
[ 3 ] Nanjing Zhou Ninglin Adv Mat Technol Co Ltd, Nanjing 211505, Jiangsu, Peoples R China
[ 4 ] Nanjing Normal Univ, Coll Life Sci, Jiangsu Key Lab Mol & Med Biotechnol, Nanjing 210023, Jiangsu, Peoples R China

CHEMICAL ENGINEERING JOURNAL,201712,330,442-452

Carbon dots could be extended in biological applications for drug delivery and photothermal therapeutics due to their ability to improving therapeutic effect and reducing side effects. Here, we use doxorubicin (DOX) as the model drug, the amino and carboxyl coated magnetofluorescent carbon quantum dots (GdN@CQDs) as a carrier, Genipin (GP) as cross-linking agent to design and prepare a multifunctional drug delivery system triggered by near-infrared (NIR) light and pH dual-stimuli. The cytotoxicity of the nanoparticles has been examined by MTT assay. The fluorescent GdN@CQDs/GP serves as both a controllable drug release gatekeeper and a fluorescent probe for the visualization of the drug delivery process. In vitro and in vivo experiments showed that this platform can deliver anti-cancer drugs to cells, releasing them intracellular upon NIR irradiation, and effectively eliminate tumors through chemo-photothermal synergistic therapeutic effect.

文章链接:
http://www.sciencedirect.com/science/article/pii/S1385894717312858?via%3Dihub


Synthesis of lanthanum doped carbon dots for detection of mercury ion, multi-color imaging of cells and tissue, and bacteriostasis
Zhang, M (Zhang, Ming)[ 1,2 ] ; Wang, WT (Wang, Wentao)[ 4 ] ; Yuan, P (Yuan, Ping)[ 1,2 ] ; Chi, C (Chi, Cheng)[ 1,2 ] ; Zhang, J (Zhang, Jun)[ 1,2 ]*(章峻); Zhou, NL (Zhou, Ninglin)[ 1,2,3 ]*(周宁琳)

[ 1 ] Nanjing Normal Univ, Coll Chem & Mat Sci, Jiangsu Collaborat Innovat Ctr Biol Funct Mat, Nanjing 210023, Jiangsu, Peoples R China
[ 2 ] Jiangsu Engn Res Ctr Biomed Funct Mat, Jiangsu Key Lab Biofunct Mat, Nanjing 210023, Jiangsu, Peoples R China
[ 3 ] Nanjing Zhou Ninglin Adv Mat Technol Co Ltd, Nanjing 211505, Jiangsu, Peoples R China
[ 4 ] Nanjing Normal Univ, Coll Life Sci, Jiangsu Key Lab Mol & Med Biotechnol, Nanjing 210023, Jiangsu, Peoples R China

CHEMICAL ENGINEERING JOURNAL,201712,330,1137-1147

This work describes a hydrothermal method for the preparation of multi-functional carbon quantum dots of the type La-CQDs. The La-CQDs are 4.3 +/- 0.3 nm in diameter and have a good dispersion and exhibit excellent emission property and high stability, as well as excitation-dependent emission behavior with typical excitation/emission peaks at 350/460 nm. They can also be used as an effective fluorescent probe for the quenchometric determination of mercury ion in aqueous solution with a detection limit of 0.1 mu M. The particles are readily internalized by liver epithelial HepG2 cells and enable multi-color fluorescence imaging by displaying green and red emission if excited with 488 and 543 nm light, respectively. Intravenous injection of the quantum dots in nude mice, in turn, enabled tissue imaging. The La-CQDs possess abundant phosphate, hydroxyl, pyridinic, pyridine-like and pyrrole-like nitrogen groups. Therefore, they can exhibit strong fluorescence, improve the accuracy as an optical monitoring code both in vitro and in vivo, and enhance blood compatibility. In vitro investigations show that La-CQDs do not exhibit significant apoptotic effects on NIH3T3 cells even at a high concentration (2.5 mg/mL) while they exhibit improved antibactericidal capacity of the La-CQDs against grampositive S. aureus and gram-negative E. coli bacteria was also observed. No apparent pathological damages are observed in all organs during the 30-day period, which suggests that La-CQDs do not produce detectable long-term toxicological responses.
 

文章链接:
http://www.sciencedirect.com/science/article/pii/S138589471731313X?via%3Dihub
 
 


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