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刘红科教授在DALTON TRANSACTIONS发表研究论文

发布时间:17-01-13 11:46:58 文章来源:化科院 浏览次数: [ 字号:


"Head-to-head" double-hamburger-like structure of di-ruthenated d(GpG) adducts of monofunctional Ru-arene anticancer complexes
Liu, HK (Liu, Hong-Ke)[ 1 ]*(刘红科); Kostrhunova, H (Kostrhunova, Hana)[ 2 ] ; Habtemariam, A (Habtemariam, Abraha)[ 3 ] ; Kong, YQ (Kong, Yaqiong)[ 1 ] ; Deeth, RJ (Deeth, Robert J.)[ 3 ] ; Brabec, V (Brabec, Viktor)[ 2 ]*; Sadler, PJ (Sadler, Peter J.)[ 3 ]*

[ 1 ] Nanjing Normal Univ, Coll Chem & Mat Sci, Jiangsu Key Lab Biofunct Mat, Jiangsu Collaborat Innovat Ctr Biomed Funct Mat, Nanjing 210046, Jiangsu, Peoples R China
[ 2 ] Acad Sci Czech Republic, Vvi, Inst Biophys, Kralovopolska 135, Brno 61265, Czech Republic
[ 3 ] Univ Warwick, Dept Chem, Gibbet Hill Rd, Coventry CV4 7AL, W Midlands, England

DALTON TRANSACTIONS, Nov.2016, 45(46) 18676-18688

Guanine bases in DNA are targets for some Ru-arene anticancer complexes. We have investigated the structure of the novel di-ruthenated d(GpG) adduct Ru-2-GpG (where Ru = {(eta(2)-biphenyl)-Ru(en)}(2+) (1')) in aqueous solution. 2D NMR results indicate that there are two conformers, supported by modeling studies. The major conformer I is a novel double-hamburger-like structure with a "head-to-head" (HH) base arrangement involving hydrophobic interactions between neighboring arene rings, the first example of a HH d(GpG) adduct constructed by weak interactions. Hence there are significant differences compared to Pt-d(GpG) adducts formed by cisplatin. There is no obviously rigid bending for the major conformer I. The minor conformer II of Ru2-GpG has a back-to-back structure, with two ruthenated guanine bases flipped away from each other. 19-23 base-pair oligodeoxyribonucleotides containing central TGGT sequences di-ruthenated by 1 show no directional bending, only slightly distorted di-ruthenated duplexes, consistent with the NMR data for conformer I. The structural differences and similarities of d(GpG) residues which are di-ruthenated or cross-linked by platination are discussed in the context of the biological activity of these metal complexes.


文章链接:
http://pubs.rsc.org/en/Content/ArticleLanding/2016/DT/C6DT03356C#!divAbstract
 


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