当前位置:首页 > 科研成果 > 正文

李淑萍教授课题组和李晓东副教授课题组合作在INTERNATIONAL JOURNAL OF PHARMACEUTICS发表研究论文

发布时间:17-01-13 10:04:44 文章来源:化科院 浏览次数: [ 字号:


Novel morphology change of Au-Methotrexate conjugates: From nanochains to discrete nanoparticles
Wang, WY (Wang, Wei-Yuan)[ 1 ] ; Zhao, XF (Zhao, Xiu-Fen)[ 1 ] ; Ju, XH (Ju, Xiao-Han)[ 1 ] ; Wang, Y (Wang, Yu)[ 1 ] ; Wang, L (Wang, Lin)[ 1 ] ; Li, SP (Li, Shu-Ping)[ 1,2 ]*(李淑萍); Li, XD (Li, Xiao-Dong)[ 1 ]*(李晓东)

[ 1 ] Nanjing Normal Univ, Coll Chem & Mat Sci, Jiangsu Key Lab Biofunct Mat, Nanjing 210023, Jiangsu, Peoples R China
[ 2 ] Huaiyin Inst Technol, Jiangsu Prov Key Lab Palygorskite Sci & Appl Tech, Huaian 223003, Peoples R China

INTERNATIONAL JOURNAL OF PHARMACEUTICS, Dec.2016, 515(1-2), 221-232

A novel morphology change of Au-methotrexate (Au-MTX) conjugates that could transform from nanochains to discrete nanoparticles was achieved by a simple, one-pot, and hydrothermal growth method. Herein, MTX was used efficiently as a complex-forming agent, reducing agent, capping agent, and importantly a targeting anticancer drug. The formation mechanism suggested a similarity with the molecular imprinting technology. The Au-MTX complex induced the MTX molecules to selectively adsorb on different crystal facets of gold nanoparticles (AuNPs) and then formed gold nanospheres. Moreover, the abundantly binding MTX molecules promoted directional alignment of these gold nanospheres to further form nanochains. More interestingly, the linear structures gradually changed into discrete nanoparticles by adding different amount of ethylene diamine tetra (methylene phosphonic acid) (EDTMPA) into the initial reaction solution, which likely arose from the strong electrostatic effect of the negatively charged phosphonic acid groups. Compared with the as-prepared nanochains, the resultant discrete nanoparticles showed almost equal drug loading capacity but with higher drug release control, colloidal stability, and in vitro anticancer activity.


文章链接:
http://www.sciencedirect.com/science/article/pii/S0378517316309565
 


发布:化科院  打印此稿 | 关闭窗口