
姓名:方红宝
职称:研究员
学历学位:博士研究生,理学学位
Email:fanghb@njnu.edu.cn
个人简介:
方红宝,南京师范大学特聘研究员,中国博士后创新计划入选者。2023年09月至今作为高层次青年人才引进入职南京师范大学化学与材料科学学院。2013年-2020年在南京大学化学化工学院攻读硕士和博士,师从何卫江教授和郭子建教授;2020年-2023年在南京大学生命科学学院和化学与生物医药创新研究院(ChemBIC)进行博士后研究,合作导师为何卫江教授、董磊教授和郭子建教授,主要从事生物物种识别和细胞器互作成像探针的开发与化学生物学应用研究工作。2019年-2020年在University of Cincinnati College of Medicine访问交流期间,利用人工智能算法辅助的超分辨荧光成像技术研究细胞器互作及其关键生物物种动态变化。目前已授权中国专利四项,并以(共同)第一作者或者通讯作者在相关领域的国际主流期刊发表十余篇,包括Nat. Commun.、Angew. Chem. Int. Ed.、ACS Nano、Biomaterials、Sci. China Chem.、Inorg. Chem. Front. 等。2021年,曾获南京大学优秀博士论文。申请和授权中国发明专利5项;目前在研项目两项,包括江苏省自然科学基金1项、江苏省高等学校面上项目1项;主持并结题科研基金三项,包括2021年度博士后创新人才支持计划,中国博士后科学基金第69批面上资助等。
研究方向:
1. 细胞器靶向的小分子荧光探针设计与合成
2. 细胞器互作的超分辨示踪与化学调控
3. 可激活抗癌金属配合物的诊疗一体化
主持项目:
1. 2021年度博士后创新人才支持计划,2021-2023(已结题)
2. 中国博士后科学基金第69批面上资助,2021-2023 (已结题)
3. 江苏省博士后科研资助计划,2021-2023 (已结题)
4. 江苏省高等学校基础科学(自然科学)研究面上项目,2023-2025 (在研)
5. 江苏省自然科学基金(青年项目),2023-2026(在研)
代表作:
1. Hongbao Fang†, Shanshan Geng†, Mingang Hao, Qixin Chen, Chunyan Liu, Zhiqi Tian, Takanori Takebe, Jun-Lin Guan, Yuncong Chen*, Zijian Guo*, Weijiang He*, Jiajie Diao*, Simultaneous Zn2+ tracking in multiple organelles using super-resolution morphology-correlated organelle identification in living cells, Nat. Commun., 2021, 12, 109.
2. Qixin Chen†, Hongbao Fang†, Xintian Shao, Zhiqi Tian, Yuming Zhang, Huaxun Fan, Kai Zhang*, Weijiang He*, Zijian Guo, Jiajie Diao*, A dual-labeling probe to track functional mitochondria–lysosome interactions in live cells, Nat. Commun., 2020, 11, 6290.
3. Hongbao Fang, Yuncong Chen*, Zhiyong Jiang, Weijiang He*, Zijian Guo*, Fluorescent Probes for Biological Species and Microenvironments:from Rational Design to Bioimaging Applications, Acc. Chem. Res., 2023, 56, 258-269.
4. Liu-Yi Liu†, Hongbao Fang†, Qixin Chen†, Michael Ho-Yeung Chan†, Kang-Nan Wang, Wenting Liu, Zhiqi Tian, Maggie Ng, Jiajie Diao*, Zong-Wan Mao*, Vivian Wing-Wah Yam*, Multiple-color Platinum complex with super-large stokes shift for super-resolution imaging of autolysosome escape, Angew. Chem. Int. Ed., 2020, 59, 19229-19236.
5. Hongbao Fang, Shankun Yao, Qixin Chen, Chunyan Liu, Yuqi Cai, Shanshan Geng, Yang Bai, Zhiqi Tian, Amanda L. Zacharias, Takanori Takebe, Yuncong Chen*, Zijian Guo, Weijiang He*, Jiajie Diao*, De novo-designed near-infrared nanoaggregates for super-resolution monitoring of lysosomes in cells, in whole organoids, and in vivo, ACS Nano, 2019, 12, 14426-14436.
6. Hongbao Fang†, Lianting Hu†, Qixin Chen†, Shanshan Geng, Kangqiang Qiu, Chengjun Wang, Mingang Hao, Zhiqi Tian, Huimin Chen, Lei Liu, Jun-Lin Guan, Yuncong Chen*, Zijian Guo*, Weijiang He*, Jiajie Diao*, An ER-targeted “reserve-release” fluorogen for topological quantification of reticulophagy, Biomaterials, 2023, 292, 121929.
7. Hongbao Fang, Yuncong Chen*, Yanjun Wang, Shanshan Geng, Shankun Yao, Dongfan Song, Weijiang He*, Zijian Guo, A dual-modal probe for NIR fluorogenic and ratiometric photoacoustic imaging of Cys/Hcy in vivo, Sci. China Chem., 2020, 63, 699-706.
8. Hongbao Fang, Yuncong Chen*, Shanshan Geng, Shankun Yao, Zijian Guo*, Weijiang He*, Super-resolution imaging of mitochondrial HClO during cell ferroptosis using a NIR fluorescent probe, Anal. Chem., 2022, 94, 17904−17912.
9. Hongbao Fang, Yuncong Chen*, Zijian Guo*, Weijiang He*, Recent advances in Zn2+ imaging: From organelles to in vivo applications, Curr. Opin. Chem. Biol., 2023, 76, 102378.
10. Hongbao Fang, Chengjun Wang, Yuncong Chen*, Zhongyan Chen, Shankun Yao, Shiping Yang*, Lei Dong, Zijian Guo, and Weijiang He*, A photoacoustic Zn2+ sensor based on a merocyanine/xanthene-6-ol hybrid chromophore and its ratiometric imaging in mice, Inorg. Chem. Front., 2021, 8, 3402-3410.