魏少华,教授,博士生导师。本科毕业于南京师范大学化学系,硕士毕业于华东理工大学精细化工系,博士毕业于上海交通大学化学化工学院。2008年赴澳大利亚国立大学访学。感兴趣的研究领域是应用有机化学、药物分析及功能材料等,主要进行光敏抗癌药物的结构设计、合成、光动力性质与抗肿癌活性研究。
E-mail:weishaohua@njnu.edu.cn
主要科研项目:
1. 基于Type I型光动力机制的酞菁类HIF-α抑制剂高效抗肿瘤策略(国家自然科学基金面上项目,主持人)
2. 直接污染物现场监测技术的全产业链应用示范,(国家重点研发计划子项目,主持人)
3. 基于过氧化氢爆发效应的乏氧实体肿瘤光动力治疗体系构建及活性研究(国家自然科学基金面上项目,主持人);
4. 多胺类酞菁侧链荷电性质与光敏抗肿瘤活性构效关系研究(江苏省高校自然科学研究重大项目,主持人);
5. 酞菁/二氧化硅靶向给药体系的构建及其光动力活性研究(国家自然科学基金面上项目,主持人);
6. 磷胺两亲性不对称酞菁设计与光敏活性构效关系的研究(国家自然科学基金面上项目,主持人);
7. 核壳结构纳米二氧化硅在光动力疗法中的应用研究(教育部科学技术研究重点项目,主持人);
代表性科技论文:
1. Wang, C.C.; Xia, Y.Y.; Wu, G.; Zhou, L.*; Wei, S.H.*, Synthesis of sub-1 nm 2D transitional metal oxides via anion exchange-bonds cleavage cascade reactions. Chemical Engineering Journal 2022, 437, 135230.
2. Kong, L.L.; Wang, C.C.; Yang, W.; Zhou, L.*; Wei, S.H.*, The ultrathin palladium nanosheets for sensitive and visual Hg2+ detection in the food chain. Journal of Hazardous Materials 2022, 427, 128135.
3. Zhan, Q.C.; Shi, X.Q.; Fan, D.; Zhou, L.*; Wei, S.H.*, Solvent mixing generating air bubbles as a template for polydopamine nanobowl fabrication: Underlying mechanism, nanomotor assembly and application in cancer treatment. Chemical Engineering Journal 2021, 404, 126443.
4. Xu, K.K.; Yao, H.; Fan, D.; Zhou, L.*; Wei, S.H.*, Hyaluronic acid thiol modified injectable hydrogel: Synthesis, characterization, drug release, cellular drug uptake and anticancer activity. Carbohydrate Polymers 2021, 254, 117286.
5. Wang, C.C.; Li, Y.Q.; Yang, W.; Zhou, L.*; Wei, S.H.*, Nanozyme with Robust Catalase Activity by Multiple Mechanisms and Its Application for Hypoxic Tumor Treatment. Advanced Healthcare Materials 2021, 10, 2100601.
6. Zhan, Q.C.; Shi, X.Q.; Zhou, J.H.; Zhou, L.*; Wei, S.H.*, Drug-Controlled Release Based on Complementary Base Pairing Rules for Photodynamic-Photothermal Synergistic Tumor Treatment. Small 2019, 15, 1803926.
7. Wang, T.; Hu, J.H.; Luo, H.; Li, H.Y.; Zhou, J.H.; Zhou, L.*; Wei, S.H.*, Photosensitizer and Autophagy Promoter Coloaded ROS-Responsive Dendrimer-Assembled Carrier for Synergistic Enhancement of Tumor Growth Suppression. Small 2018, 14, 1802337.
8. Jiang, B.; Wang, L.P.; Wu, G.; Zhou, L.*; Wei, S.H*., Synergistic anticancer theragnostic study of a core-shell structured galvanic cell. Colloids and Surfaces B-Biointerfaces 2022, 209, 112154.
9. Wu, G.; Jiang, B.; Zhou, L.; Wang, A.*; Wei, S.H.*, Coconut-shell-derived activated carbon for NIR photo-activated synergistic photothermal-chemodynamic cancer therapy. Journal of Materials Chemistry B 2021, 9, 2447.
10. Li, Y.Q.; Wang, C.C.; Zhou, L.*; Wei, S.H.*, A 2-pyridone modified zinc phthalocyanine with three-in-one multiple functions for photodynamic therapy. Chemical Communications 2021, 57, 3127.