刘平副教授、孙培培教授课题组在JOURNAL OF ORGANIC CHEMISTRY发表研究论文

时间:2020-01-16 来源:化科院 点击数:

An Approach to Quinoline-Fused Imidazopyridines via CDC of Ethers with Imidazopyridines under Metal-Free Conditions
Lian, GF (Lian, Guifang)[ 1 ] ; Li, JY (Li, Jingyu)[ 1 ] ; Liu, P (Liu, Ping)[ 1 ]*(刘平) ; Sun, PP (Sun, Peipei)[ 1 ]*(孙培培)


[ 1 ] Nanjing Normal Univ, Jiangsu Collaborat Innovat Ctr Biomed Funct Mat, Sch Chem & Mat Sci, Jiangsu Prov Key Lab Mat Cycle Proc & Pollut Cont, Nanjing 210023, Jiangsu, Peoples R China


JOURNAL OF ORGANIC CHEMISTRY,201912,84(24),16346-16354


An NH4I-catalyzed cross-dehydrogenative coupling (CDC) reaction of ethers with imidazopyridine cascade cyclization under transition-metal-free conditions has been developed. Cheap, commercially available ethers were used as both reagents and solvents, and green aqueous H2O2 was used as an oxidizing agent. A series of substituents on 2-(2-aminoaryl) imidazo[1,2-a]pyridines were tolerated, and the reaction gave quinoline-fused imidazopyridines in moderate to good yields.

文章链接:
https://pubs.acs.org/doi/10.1021/acs.joc.9b02897

Copyright © 2009-20010 南京师范大学 化学与材料科学学院. All rights reserved.