孙培培教授课题组在JOURNAL OF ORGANIC CHEMISTRY发表研究论文
Photoredox-Catalyzed Radical Cascade Reaction To Synthesize Fluorinated Pyrrolo[1,2-d]benzodiazepine Derivatives
Lian, GF (Lian, Guifang)[ 1 ] ; Li, JY (Li, Jingyu)[ 1 ] ; Liu, P (Liu, Ping)[ 1 ] ; Sun, PP (Sun, Peipei)[ 1 ]*（孙培培）
[ 1 ] Nanjing Normal Univ, Sch Chem & Mat Sci, Jiangsu Collaborat Innovat Ctr Biomed Funct Mat, Jiangsu Prov Key Lab Mat Cycle Proc & Pollut Cont, Nanjing 210023, Jiangsu, Peoples R China
JOURNAL OF ORGANIC CHEMISTRY，201907,84(14),9322-9329
A new photoredox-catalyzed cascade reaction is described to access fluorinated pyrrolo[1,2-d]-benzodiazepine derivatives under mild conditions. In this process, single electron transfer (SET) between the excited state photocatalyst fac-Ir(ppy)(3) and ethyl bromodifluoroacetate initiated the regioselective radical addition to a wide range of 2-(1H-pyrrol-l-yl) anilines or indol-substituted anilines, followed by another SET process and intramolecular amidation.