A Safe and Efficient Strategy for the Rapid Elimination of Blood Lead In Vivo Based on a Capture-Fix-Separate Mechanism
Wan, MM (Wan, Mi Mi)[ 1 ] ; Xu, TT (Xu, Ting Ting)[ 1 ] ; Chi, B (Chi, Bo)[ 2 ] ; Wang, M (Wang, Meng)[ 1 ] ; Huang, YY (Huang, Yangyang)[ 1 ] ; Wang, Q (Wang, Qi)[ 1 ] ; Li, T (Li, Ting)[ 1 ] ; Yan, WQ (Yan, Wen Qiang)[ 3 ] ; Chen, H (Chen, Huan)[ 1 ] ; Xu, P (Xu, Ping)[ 1 ] ; Mao, C (Mao, Chun)[ 1 ]*（毛春） ; Zhao, B (Zhao, Bo)[ 1 ] ; Shen, J (Shen, Jian)[ 1 ]*（沈健） ; Xu, H (Xu, Hong)[ 2 ] ; Shi, DQ (Shi, Dong Quan)[ 3 ]*
[ 1 ] Nanjing Normal Univ, Sch Chem & Mat Sci, Natl & Local Joint Engn Res Ctr Biomed Funct Mat, Nanjing 210023, Jiangsu, Peoples R China
[ 2 ] Nanjing Tech Univ, Coll Food Sci & Light Ind, Jiangsu Natl Synerget Innovat Ctr Adv Mat, State Key Lab Mat Oriented Chem Engn, Nanjing 211816, Jiangsu, Peoples R China
[ 3 ] Nanjing Univ, Sch Med, Nanjing Drum Tower Hosp, Dept Sports Med & Adult Reconstruct Surg, Nanjing 210008, Peoples R China
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION，201907,58(31),10582-10586
Lead poisoning is an important problem because of its serious effects on human health. Yet a solution is not available due to an incomplete understanding of the state of lead ions in blood. Since most blood lead binds to hemoglobin (Hb) in red blood cells, identifying and capturing lead-contaminated Hb in RBCs is important. Herein, a magnetic blood lead remover with hyperbranched poly(amidoamine)s (HPAM) as template/co-adsorbent and core-shell mesoporous structure was synthesized. Lead-containing Hb was selectively captured and then fixed by mesoporous channels. The magnetic separation technology was used to separate the magnetic remover from blood. A related blood lead clean-up apparatus was used to remove lead from the blood of a pig in vivo. Results of physical/chemical characterizations, biocompatibility experiments, animal tests, and theoretical simulation verify the safety and efficiency of this removal strategy and the high efficiency of the blood lead clean-up apparatus.