Use of an NIR-light-responsive CO nanodonor to improve the EPR effect in photothermal cancer treatment
Wang, CC (Wang, Chongchong)[ 1 ] ; Li, YQ (Li, Yanqing)[ 1 ] ; Shi, XQ (Shi, Xianqing)[ 1 ] ; Zhou, JH (Zhou, Jiahong)[ 1 ] ; Zhou, L (Zhou, Lin)[ 1 ]*（周林）; Wei, SH (Wei, Shaohua)[ 1 ]*（魏少华）
[ 1 ] Nanjing Normal Univ, Jiangsu Collaborat Innovat Ctr Biomed Funct Mat, Jiangsu Key Lab Biofunct Mat, Coll Chem & Mat Sci,Key Lab Appl Photochem, Nanjing 210023, Jiangsu, Peoples R China
The carbon monoxide (CO)-carrying palladium nanosheet (PdNS-CO) was exploited as a photothermally triggered donor of CO. Irradiating material containing PdNS-CO with 808 nm-wavelength light caused a rapid heating of the material, triggering a release of CO. The enhanced permeability and retention (EPR) effect was found to be improved by such released CO and resulted in an increase in the accumulation of PdNS-CO at tumors and hence promoted its use in photothermal therapy (PTT) using a low laser power density.