沈健教授和周宁琳教授课题组在INTERNATIONAL JOURNAL OF NANOMEDICINE发表研究论文

时间:2018-12-04 来源: 点击数:

Near-infrared light-mediated photodynamicphotothermal therapy nanoplatform by the assembly of Fe3O4 carbon dots with graphitic black phosphorus quantum dots
Zhang, M (Zhang, Ming)[ 1,2 ] ; Wang, WT (Wang, Wentao)[ 3 ] ; Cui, YJ (Cui, Yingjun)[ 2 ] ; Zhou, NL (Zhou, Ninglin)[ 1,4 ]*(周宁琳); Shen, J (Shen, Jian)[ 1 ]*(沈健)


[ 1 ] Ctr Biomed Funct Mat, Jiangsu Engn Res, Coll Chem & Mat Sci, Jiangsu Collaborat Innovat Ctr Biol Funct Mat, Nanjing, Jiangsu, Peoples R China
[ 2 ] Florida Int Univ, Dept Biol Sci, Miami, FL 33199 USA
[ 3 ] Nanjing Normal Univ, Coll Life Sci, Jiangsu Key Lab Mol & Med Biotechnol, Nanjing, Jiangsu, Peoples R China
[ 4 ] Nanjing Zhou Ninglin Adv Mat Technol Co Ltd, Fac Mat Dev, Nanjing, Jiangsu, Peoples R China


INTERNATIONAL JOURNAL OF NANOMEDICINE,201805,13,2803-2819


Background: Recently, combined photodynamic therapy (PDT) and photothermal therapy (PTT) has become a desired treatment for cancer. However, the development of economic, highefficiency, and safe photosensitizers/photothermal agents remains a significant challenge.
Methods: A novel nanocomposite has been developed via the assembly of iron oxide carbon dot (Fe3O4-CDs) nanoparticles and black phosphorus quantum dots (genipin [GP]-polyglutamic acid [PGA]-Fe3O4-CDs@ BPQDs), and this nanocomposite shows a broad light-absorption band and a photodegradable character.
Results: In vitro and in vivo assays indicated that GP-PGA-Fe3O4-CDs@ BPQDs were highly biocompatible and exhibited excellent tumor-inhibition efficacy, due to the synergistic PTT and PDT via a near-infrared laser. Importantly, in vivo tumor magnetic resonance imaging (MRI) results illustrated that GP-PGA-Fe3O4-CDs@ BPQDs can be specifically applied for enhanced T-2 MRI of tumors. This work presents the first combined application of a PDT and PTT effect deriving from BPQDs and MRI from Fe3O4-CDs, which may promote utilization of black BPQDs in biomedicine.
Conclusion: As expected, GP-PGA-Fe3O4-CDs@ BPQDs displayed a dramatically enhanced ability to destroy tumor cells, due to the synergistic combination of PTT and PDT.


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