Magnetofluorescent Carbon Quantum Dot Decorated Multiwalled Carbon Nanotubes for Dual-Modal Targeted Imaging in Chemo-Photothermal Synergistic Therapy
Zhang, M (Zhang, Ming)[ 1,4 ] ; Wang, WT (Wang, Wentao)[ 2 ] ; Cui, YJ (Cui, Yingjun)[ 4 ] ; Zhou, NL (Zhou, Ninglin)[ 1,3 ]*（周宁琳） ; Shen, J (Shen, Jian)[ 1 ]*（沈健）
[ 1 ] Coll Chem & Mat Sci, Ctr Biomed Funct Mat, Jiangsu Collaborat Innovat Ctr Biol Funct Mat, Jiangsu Key Lab Biofunct Mat,Jiangsu Engn Researc, Nanjing 210023, Jiangsu, Peoples R China
[ 2 ] Nanjing Normal Univ, Coll Life Sci, Jiangsu Key Lab Mol & Med Biotechnol, Nanjing 210023, Jiangsu, Peoples R China
[ 3 ] Nanjing Zhou Ninglin Adv Mat Technol Co Ltd, Nanjing 211505, Jiangsu, Peoples R China
[ 4 ] Florida Int Univ, Dept Biol Sci, Miami, FL 33199 USA
ACS BIOMATERIALS SCIENCE & ENGINEERING，201801,4(1), 151-162
Magnetofluorescent nanoparticles with diagnostic and therapeutic functions show great promise in nanomedicine. Here, we report the magnetofluorescent carbon nanotubes (CNTs)/doxorubicin (DOX) nanocomposites and their functions act in synergetic chemo-photothermal synergistic therapy (Chemo/PTT) in cancer excision. Magnetofluorescent CNTs conjugated with a folic acid (FA-GdN@CQDs-MWCNTs) were targets for dual-modal fluorescence (FL)/magnetic resonance (MR) imaging. Experiments in vitro and in vivo identified FA-GdN@CQDs-MWCNTs with low toxicity, and good biocompatibility. Moreover, FA-GdN@CQDs-MWCNTs whose release can be fostered by pH and NIR light dual-stimuli had been proved to be available for loading DOX. Following nuclear translocations, FA-GdN@CQDs-MWCNTs were engineered to deliver DOX that targeted the nuclei. In vivo experiment indicates that the Chemo/PTT, as compared with the respective single treatment, can significantly control tumor growth. In addition, Chemo/PTT was not shown to render any appreciable toxicity. These findings suggest that the FA-GdN@CQDs-MWCNTs/DOX could function as a multifunctional platform for simultaneous FL/MR imaging, PTT therapy, and drug delivery.