刘平副教授和孙培培教授课题组在ORGANIC & BIOMOLECULAR CHEMISTRY发表研究论文

时间:2018-02-09 来源:化科院 点击数:

Synthesis of trifluoroalkyl or difluoroalkyl phenanthridine derivatives via cascade reaction using an intramolecular cyano group as a radical acceptor under photoredox catalysis

Liu, X (Liu, Xu)[ 1 ] ; Wu, ZJ (Wu, Zhongjie)[ 1 ] ; Zhang, ZG (Zhang, Zeguo)[ 1 ] ; Liu, P (Liu, Ping)[ 1 ]*(刘平); Sun, PP (Sun, Peipei)[ 1 ]*(孙培培)

Nanjing Normal Univ, Coll Chem & Mat Sci, Jiangsu Prov Key Lab Mat Cycle Proc & Pollut Cont, Jiangsu Collaborat Innovat Ctr Biomed Funct Mat, Nanjing 210023, Jiangsu, Peoples R China

ORGANIC & BIOMOLECULAR CHEMISTRY,201801,16(3),414-423

In the presence of Ru(phen)(3)Cl-2 or fac-Ir(ppy)(3) under visible-light irradiation, the addition of fluorinated radicals to N-arylacrylamides followed by an intramolecular cyano group insertion cascade cyclization process produced trifluoroalkyl or difluoroalkyl phenanthridine derivatives in moderate to good yields. Three easily available fluoroalkylated reagents CF3SO2Cl, BrCF2CO2Et and BrCF2PO(OEt)(2) were used as the sources of fluorinated radicals.

文章链接:

http://pubs.rsc.org/en/Content/ArticleLanding/2018/OB/C7OB02804K#!divAbstract

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