刘平副教授和孙培培教授课题组在ORGANIC CHEMISTRY FRONTIERS发表研究论文

时间:2018-02-09 来源:化科院 点击数:

Photoredox-catalyzed cascade addition/cyclization of N-propargyl aromatic amines: access to 3-difluoroacetylated or 3-fluoroacetylated quinolines

Deng, QF (Deng, Qinfei)[ 1 ] ; Xu, Y (Xu, Yan)[ 1 ] ; Liu, P (Liu, Ping)[ 1 ]*(刘平); Tan, LP (Tan, Liping)[ 1 ] ; Sun, PP (Sun, Peipei)[ 1 ]*(孙培培)

[ 1 ] Nanjing Normal Univ, Coll Chem & Mat Sci, Jiangsu Collaborat Innovat Ctr Biomed Funct Mat, Jiangsu Prov Key Lab Mat Cycle Proc & Pollut Cont, Nanjing 210023, Jiangsu, Peoples R China

ORGANIC CHEMISTRY FRONTIERS,201801,5(1),19-23

3-Difluoroacetylated quinolines and 3-fluoroacetylated quinolines were synthesized via a visible-light-induced cascade addition/cyclization of N-propargyl aromatic amines with ethyl bromodifluoroacetate or ethyl bromofluoroacetate catalyzed by fac-Ir(ppy)(3) under mild conditions. For the substrates bearing various substituents on the aniline ring and benzene ring, the reaction proceeded smoothly to give the corresponding difluoroacetylated or fluoroacetylated quinolines in moderate to high yields.

文章链接:

http://pubs.rsc.org/en/Content/ArticleLanding/2018/QO/C7QO00714K#!divAbstract

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