陈良安

时间:2019-10-12 来源:化科院 点击数:

    姓名:陈良安

       职称:教授

       学科:有机化学

       学位学历:博士

       实验室:化育楼503,办公室:化育楼621


       Email: lachen@njnu.edu.cn; lachen@foxmail.com

       Google Scholar: scholar.google.com/citations?hl=en&user=wAqtvMoAAAAJ


教育和工作经历:

2019.06-至今  南京师范大学化学与材料科学学院,教授


2018.03-2019.05 印第安纳大学布鲁明顿分校化学系, 博士后(导师:Kevin Brown教授)

-镍催化烯烃的多样性精准双官能团化构建复杂分子的新方法


2015.01-2018.03 美国哥伦比亚大学化学系, 博士后(导师:James Leighton教授)

-具有重要生理活性天然产物的全合成及其类似物的生物活性评价


2011.09-2014.12 厦门大学化学系, 理学博士(导师:Eric Meggers教授)

-唯金属中心手性八面体催化剂的发现及在不对称催化中的应用


2008.09-2011.09 厦门大学化学系,理学硕士(导师:黄培强、王爱娥教授)

-不对称催化与天然产物全合成研究


2004.09-2008.07 阜阳师范大学化学系,理学学士


研究方向:

研究领域涉及有机合成、不对称催化、过渡金属催化和天然产物全合成;课题组致力于开发Fragment-Oriented Synthesis(FOS)步骤经济性和实用性的有机合成方法学,并实现具有重要生理活性天然产物的全合成和相关药物分子的开发


Selected Publications

1. L.-A Chen, A. R. Lear, P. Gao and M. K. Brown*, “Nickel-Catalyzed Arylboration of Alkenylarenes: Synthesis of Boron-Substituted Quaternary Carbons and Regiodivergent Reactions”. Angew. Chem. Int. Ed. 2019, 58, 10956-10960


2. P. Gao#, L.-A Chen# and M. K. Brown*, “Nickel-Catalyzed Stereoselective Diarylation of Alkenylarenes,” J. Am. Chem. Soc. 2018, 140, 10653-10657. (#equal contribution, highlighted by Synfacts and X-mol, most read articles in August 2018)


3. L.-A. Chen, M. A. Ashley and J. L. Leighton*, “Evolution of an Efficient and Scalable Nine-Step (Longest Linear Sequence) Synthesis of Zincophorin Methyl Ester”, J. Am. Chem. Soc. 2017, 139, 4568-4573. (Highlighted by Chemistry World and X-mol)

4. L.-A. Chen, W. Xu, B. Huang, J. Ma, L. Wang, J. Xi, K. Harms, L. Gong* and E. Meggers*, “Asymmetric Catalysis with an Inert Chiral-at-Metal Iridium Complex”, J. Am. Chem. Soc. 2013, 135, 10598-10601. (Cover Paper, highlighted by JACS Spotlights and Synfacts)

5. L.-A. Chen, X. Tang, J. Xi, W. Xu, L. Gong* and E. Meggers*, “Chiral-at-Metal Octahedral Iridium Catalyst for Asymmetric Construction of an All-Carbon Quaternary Stereocenter”, Angew. Chem. Int. Ed. 2013, 125, 14271-14275. (Highlighted by Synfacts)


6. H. Huo, X. Shen, C. Wang, L. Zhang, P. Röse, L.-A. Chen, K. Harms, M. Marsch, G. Hilt and E. Meggers*, “Asymmetric Photoredox Transition Metal Catalysis Activated by Visible Light”, Nature, 2014, 515, 100-103. (Highlighted by Nature, C&EN News and Synfacts)



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